AG Pneumologie

AG Pneumologie

About / Biography 

  • Professor Manfred Ballmann has a profound clinical and research interest in Cystic Fibrosis, chronic lung diseases and allergy 
  • Professor Ballmann is available for student supervision
  • Orcid: 0000-0003-4480-1312
     
  • Team members
    - Anja Keßler MD, Paediatrician training in paediatric pulmonology
    - Nadja Züfle-Lemke, MD Paediatrician training in paediatric pulmonology
    - Dagmar-Christiane Fischer Prof. PhD
    - Julia Hildebrandt, Physician  training in paediatrics
    - Sandra Braunroth, CF nurse and research nurse
    - Anja Rahn, Technician (medical)
    - Alexandra Giering, CF nurse
    - Susanne Seiter, Physiotherapist
    - Christian Grabautzki, Psychologist
    - Dana Schmidt, Diatrician
    - Jeanette Bigus, Social worker
    - PhD students:
             Luisa Saegebrecht
             Isabell Weber

Research Projects 

  • The focus of our research is on pathophysiology, diagnosis and therapy of inherited (CF) and acquired impairments of lung function. The latter is assessed not only by "classical" spirometry but utilization of non-invasive sensitive tests, i.e. lung clearance index and CO diffusion capacity.
  • Current CF projects deal with
  • the improvement of CF care via telemedicine,  
  • diagnosis and therapy of CF related diabetes mellitus including sensitive
       methods for detection of vascular and/or retinal (ophthalmological?)   
       complications 
  • basic research related to CFTR 
  • Impact of autoinflammatory/autoimmunological diseases and treatment on lung function 

Research Awards (selection) 

Collaborations (selection)

Publications – Selected recent Original ArticlesUTATIONAL BIOLOGY

  • Hildebrandt J, Rahn A, Kessler A, Speth F, Fischer D, Ballmann M. Lung Clearance Index and diffusion capacity for CO to detect early functional pulmonary impairment in children with rheumatic diseases. BMC Paediatric Rheumatology 2021 in press
  • Rauscher R, Bampia G, Guevara-Ferrera M, Santosa L, Joshib D, Marka D, Strugd L, a M. Rommens J, Ballmann M, Sorscher E, Oliverb K and Zoya Ignatova. Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity. PNAS 2021 Vol. 118 No. 4 e2010612118; doi.org/10.1073/pnas.2010612118 | 1 of 8
  • Ballmann M, Prinz N, Glass A, Holl R. Comment on "Effect of one-year lumacaftor-ivacaftor treatment on glucose tolerance abnormalities in cystic fibrosis patients"JCyst Fibros. 2020 Sep;19(5):839. doi: 10.1016/j.jcf.2020.04.009.
  • Keßler A, Kragl U, Glass Ä, Schmidt S, Fischer DC, Ballmann M.
    Exhaled nitric oxide can't replace the methacholine challenge in suspected pediatric asthma.Respir Med. 2019 Oct;157:21-25. doi: 10.1016/j.rmed.2019.08.008.
  • Ballmann M, Holl RW. Treatment of cystic fibrosis-related diabetes - Authors' reply Lancet Diabetes Endocrinol. 2018 Mar;6(3):167-168 
  • Ballmann M, Hubert D, Assael BM, Staab D, Hebestreit A, Naehrlich L, Nickolay T, Prinz N, Holl RW; CFRD Study Group Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial. Lancet Diabetes Endocrinol. 2018 Feb;6(2):114-121 
  • Schmid F, Olbertz DM, Ballmann M The use of high-flow nasal cannula (HFNC) as respiratory support in neonatal and pediatric intensive care units in Germany - A nationwide survey. Respir Med. 2017 Oct;131:210-214 
     
    Complete list of publications available here

Publications – Selected Review/Guidline Articles

  • Hammermann J, Claßen M, Schmidt S, Bend J, Ballmann M, et al.
    S3-Leitlinie: Mukoviszidose bei Kindern in den ersten beiden Lebensjahren,
    Diagnostik und Therapie; AWMF online, AWMF-Registernummer 026 – 024; Klasse S3, Version vom 6.3.2020
  • Müller F, Bend J, Huttegger I, Möller A, Schwarz C, Abele-Horn M, Ballmann M et al S3-Leitlinie: Lungenerkrankung bei Mukoviszidose, Modul 1: Diagnostik und Therapie nach dem ersten Nachweis von Pseudomonas aeruginosa. Monatsschrift Kinderheilkd 2015;163:590-599  doi: 10.1007/s00112-015-3354-3
  • Kurzidim L and Ballmann M. Asthma update 2017, Omnimed online, Päd 2017 (4) 232-239
  • Ballmann M. Mutationsspezifische Therapie bei zystischer Fibrose Pädiatr. Praxis 2015/2016; 85:193-201
  • Koerner-Rettberg C, Ballmann M Colistimethate sodium for the treatment of chronic pulmonary infection in cystic fibrosis: an evidence-based review of its place in therapy. Core Evid. 2014 Sep 19; 9: 99-112. 
  • Ballmann M, Smyth A, Geller DE Therapeutic approaches to chronic cystic fibrosis respiratory infections with available, emerging aerosolized antibiotics. Respir Med. 2011 Dec;105 Suppl 2:S2-8 
  • Gottlieb J, Ballmann M, von Mallinckrodt C, Staab D, Smaczny C, Simon A, Welte T, Wagner TO. Lung transplantation in cystic fibrosis--a position paper. Pneumologie. 2009 Aug;63(8):451-60
  • Castellani C, Southern KW, Brownlee K, Dankert Roelse J, Duff A, Farrell M, Mehta A, Munck A, Pollitt R, Sermet-Gaudelus I, Wilcken B, Ballmann M, Corbetta C, de Monestrol I, Farrell P, Feilcke M, Férec C, Gartner S, Gaskin K, Hammermann J, Kashirskaya N, Loeber G, Macek M Jr, Mehta G, Reiman A, Rizzotti P, Sammon A, Sands D, Smyth A, Sommerburg O, Torresani T, Travert G, Vernooij A, Elborn S. European best practice guidelines for cystic fibrosis neonatal screening. J Cyst Fibros. 2009 May;8(3):153-73 
  • De Jonge HR, Ballmann M, Veeze H, Bronsveld I, Stanke F, Tümmler B, Sinaasappel M. Ex vivo CF diagnosis by intestinal current measurements (ICM) in small aperture, circulating Ussing chambers. J Cyst Fibros. 2004 Aug;3 Suppl 2:159-63

Complete list of publications available here

Funding