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AG Neuropädiatrie

About / Biography

  • Professor Bertsche is a clinician scientist trained in General Pediatrics and Neuropediatrics, and has a profound clinical and research interest in pediatric epileptology , especially in drug therapy safety, in social pediatric aspects, and in pathomechanisms of the disease. Furthermore, her interest is on neuroprotection in the immature brain.
  • Professor Bertsche is available for student supervision

Research Projects

  • The focus of our research is on drug therapy safety and social pediatric aspects in pediatric epileptology and developmental neurology.
  • A particular emphasis currently is the management of seizures and the safe administration of anticonvulsant emergency drugs by non-professionals such as parents, preschool teachers and school teachers. Moreover, we aim at improving prescription and administration of anticonvulsant long-term medication by physicians, nurses, patients and families. Besides, we investigate the perception of epilepsy and developmental disorder by patients and their families, and the effects of the disorders on daily life. We are especially interested in the perception of the effects of anticonvulsant drug therapy and adverse drug events of anticonvulsants by patients and their parents.
  • A second focus area is experimental research on pathomechanisms of epilepsy and on neuroprotection of the immature brain especially in neonatal hypoxic-ischemic encephalopathy.

Collaborations (selection) 

Publications – Original Articles (peer-reviewed; last update: June 25th, 2018)

  • Willems LM, Bertsche A, Bösebeck F, Hornemann F, Immisch I, Klein KM, Knake S, Kunz R, Kurlemann G,Langenbruch L, Möddel G, Müller-Schlüter K, von Podewills F, Reif PS, Steinhoff B, Steinig I, Rosenow F, Schubert-Bast S, Strzelczyk A. Efficiency, retention and tolerability of brivaracetam in patients with epileptic encephalopathies: A multicentre cohort study from Germany. Front Neurol 2018; in press.
  • Fisch SM, Neininger MP, Prenzel F, Bernhard MK, Hornemann F, Merkenschlager A, Kiess W, Bertsche T, Bertsche A. Experiences, expectations and fears of adolescents with epilepsy or bronchial asthma. Eur J Ped 2018; in press.
  • Schumacher PM, Kaune A, Merkenschlager A, Bernhard MK, Kiess W, Neininger MP, Bertsche A, Bertsche T. Optimizing parents‘ performance in anticonvulsive rescue medication administration. Epilepsy Behav 2018; 84:37-43.
  • Bach VA, Neininger MP, Spindler UP, Hotopp LC, Hornemann F, Syrbe S, Merkenschlager A, Kiess W, Bernhard MK, Bertsche T, Bertsche A. How do parents perceive adverse drug events of their children’s anticonvulsant medication? Eur J Paediatr Neurol 2018; 22:427-433.
  • Dumeier HK, Richter LA, Neininger MP, Prenzel F, Kiess W, Bertsche A, Bertsche T. Knowledge of allergies and performance in epinephrine auto-injector use: a controlled intervention in preschool teachers. Eur J Pediatr 2018;177:575-581.
  • Hotopp LC, Spindler UP, Bach VA, Hornemann F, Syrbe S, Andreas A, Merkenschlager A, Kiess W, Bernhard MK, Bertsche T, Neininger MP, Bertsche A. How do parents perceive the initial medical consultation on their child’s developmental disorder? Klin Padiatr 2018;230:44-49.
  • Jansen P, Neininger MP, Bernhard MK, Merkenschlager A, Kiess W, Bertsche T, Bertsche A. Knowledge and attitudes about epilepsy: A survey of high school students in Germany. Seizure 2017;51:139-144.
  • Spindler UP, Hotopp LC, Bach VA, Hornemann F, Syrbe S, Andreas A, Merkenschlager A, Kiess W, Bernhard MK, Bertsche T, Neininger MP, Bertsche A. Seizure disorders and developmental disorders: Impact on life of affected families – A structured interview. Eur J Pediatr 2017;176:1121-1129.
  • Neininger MP, Buchholz P, Frontini R, Kiess W, Siekmeyer W, Bertsche A, Siekmeyer M, Bertsche T. Incompatible intravenous drug combinations and respective nurses’ knowledge – a study in routine paediatric intensive care. Eur J Hosp Pharm 2017; epub ahead of print.
  • Dumeier HK, Neininger MP, Kaune A, Schumacher PM, Merkenschlager A, Kiess W, Bernhard MK, Bertsche T, Bertsche A. Seizure management by preschool teachers: A training concept focussing on practical skills. Seizure 2017;50:38-42.
  • Dumeier HK, Neininger MP, Bernhard MK, Merkenschlager A, Kiess W, Bertsche T, Bertsche A. Providing teachers with education on epilepsy increased their willingness to handle acute seizures in children from 1-10 years of age. Acta paediatr 2017;106:1811-1816.
  • Hoppmann J, Gesing J, Silve C, Bertsche A, Hirsch W, Kiess W, Pfäffle R, Schuster V. Phenotypic variability in a family with Acrodysostosis Type 2 caused by a novel PDE4D mutation. J Clin Res Pediatr Endocrinol 2017;9:360-365.
  • Zimmer J, Hartl S, Standfuß K, Möhn T, Bertsche A, Frontini R, Neininger MP, Bertsche T. Handling of hazardous drugs – effect of an innovative teaching session for nursing students. Nurse Educ Today 2017;49:72-78.
  • Maljevic S, Vejzovic S, Bernhard MK, Bertsche A, Weise S, Döcker M, Lerche H, Lemke JR, Merkenschlager A, Syrbe S. Novel KCNQ3 Mutation in a Large Family with Benign Familial Neonatal Epilepsy: A Rare Cause of Neonatal Seizures. Mol Syndromol 2016;7:189-196. 
  • Syrbe S, Zhorov BS, Bertsche A, Bernhard MK, Hornemann F, Mütze U, Hoffmann J, HörtnagelK, Kiess W, Hirsch FW, Lemke JR, Merkenschlager A. Phenotypic Variability from Benign Infantile Epilepsy to Ohtahara Syndrome Associated with a Novel Mutation in SCN2A. Mol Syndromol 2016;7:182-188.
  • Kaune A, Schumacher PM, Hoppe SC, Syrbe S, Bernhard MK, Frontini R, Merkenschlager A, Kiess W, Neininger MP, Bertsche A, Bertsche T. Administration of anticonvulsive rescue medication in children – discrepancies between parents’ self-reports and limited practical performance. Eur J Pediatr 2016;175:1139-1146.
  • Strasser K, Reinboth, B, Lueckemann L, Kluever V, Hoeber D, Bendix I, Herz J, Fandrey J, Bertsche A, Felderhoff-Mueser U. Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain. Brain Research 2016;1646:116-124.
  • Pauschek J, Bernhard MK, Syrbe S, Nickel P, Neininger MP, Merkenschlager A, Kiess W, Bertsche T, Bertsche A. Epilepsy in children and adolescents – disease concepts, practical knowledge, and coping. Epilepsy Behav 2016; 59:77-82.
  • Hartmann N, Neininger MP, Bernhard MK, Syrbe S, Nickel P, Merkenschlager A, Kiess W, Bertsche T, Bertsche A. Use of Complementary and Alternative Medicine (CAM) by Parents in Their Children and Adolescents with Epilepsy - Prevelance, Predictors and Parents' Assessment. Eur J Paediatr Neurol 2016;20:11-19.
  • Zimmer J, Niemann D, Seltmann K, Fischer L, Christiansen H, Frontini R, Kiess W‎, Neininger MP, Bertsche A, Bertsche T. Managing of oral medicines in paediatric oncology: Can a handbook and a pharmaceutical counselling intervention for patients and their parents prevent knowledge deficits? – A pilot study. Eur J Hosp Pharm 2016;23:100-105.
  • Neininger MP, Ullmann M, Dahse AJ, Syrbe S, Bernhard MK, Frontini R, Kiess W, Merkenschlager A, Thome U, Bertsche T, Bertsche A. Use of Levetiracetam in Neonates in Clinical Practice: A Retrospective Study at a German University Hospital. Neuropediatrics 2015;46:329-34 
  • Preuß M, Preiss S, Syrbe S, Nestler U, Fischer L, Merkenschlager A, Bertsche A, Christiansen H, Bernhard MK. Signs and symptoms of pediatric brain tumors and diagnostic value of preoperative EEG. Childs Nerv Syst 2015;31:2051-4.
  • Dumeier HK, Neininger MP, Bernhard MK, Syrbe S, Merkenschlager A, Zabel J, Kiess W, Bertsche T, Bertsche A. Knowledge and attitudes of school teachers, preschool teachers and students in teacher training about epilepsy and emergency management of seizures. Arch Dis Child 2015;100:851-5.
  • Weise S, Syrbe S, Preuss M, Bertsche A, Merkenschlager A, Bernhard MK. Pronounced reversible hyperammonemic encephalopathy associated with combined valproate-topiramate therapy in a 7-year-old girl. Springerplus 2015;4:276.
  • Syrbe S, Hedrich UB, Riesch E, Djémié T, Müller S, Møller RS, Maher B, Hernandez-Hernandez L, Synofzik M, Caglayan HS, Arslan M, Serratosa JM, Nothnagel M, May P, Krause R, Löffler H, Detert K, Dorn T, Vogt H, Krämer G, Schöls L, Mullis PE, Linnankivi T, Lehesjoki AE, Sterbova K, Craiu DC, Hoffman-Zacharska D, Korff CM, Weber YG, Steinlin M, Gallati S, Bertsche A, Bernhard MK, Merkenschlager A, Kiess W; EuroEPINOMCS RES, Gonzalez M, Züchner S, Palotie A, Suls A, De Jonghe P, Helbig I, Biskup S, Wolff M, Maljevic S, Schüle R, Sisodiya SM, Weckhuysen S, Lerche H, Lemke JR. De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nat Genet 2015;47:393-9.
  • Neininger MP, Kaune A, Bertsche A, Rink J, Musiol J, Frontini R, Prenzel F, Kiess W, Bertsche T. How to improve prescription of inhaled salbutamol by providing standardised feedback on administration: a controlled intervention pilot study with follow-up. BMC Health Serv Res 2015;15:40.
  • Tews W, Weise S, Syrbe S, Hirsch W, Viehweger A, Merkenschlager A, Bertsche A, Kiess W, Bernhard MK. Is there a predictive value of EEG and MRI after a first afebrile seizure in children? Klin Padiatr 2015;227:84-8.
  • Niemann D, Bertsche A, Meyrath D, Koepf ED, Traiser C, Seebald K, Schmitt CP, Hoffmann GF, Haefeli WE, Bertsche T. A prospective three-step intervention study to prevent medication errors in drug handling in paediatric care. J Clin Nurs 2015;24:101-14.
  • Niemann D, Bertsche A, Meyrath D, Oelsner S, Ewen AL, Pickardt B, Henhapl T, Hoffmann G, Meyburg J, Bertsche T. Drug Handling in a Paediatric Intensive CareUnit - Can Errors be Prevented by a Three-Step Intervention? Klin Padiatr 2014;226:62-7.
  • Bernhard MK, Bertsche A, Syrbe S, Weise S, Merkenschlager A. Botulinumtoxin-Injektionen bei chronischer Migräne im Jugendalter - eine frühzeitige Therapieoption in der Transition von Neuropädiatrie zur Neurologie / Botulinumtoxin injections in chronic migraine of adolescents - an early therapeutical option in the transition from neuropediatrics to neurology. Fortschr Neurol Psychiatr 2014;82:39-42.
  • Bertsche A, Neininger MP, Dahse AJ, Syrbe S, Bernhard MK, Frontini R, Kiess W, Bertsche T, Merkenschlager A. Initial anticonvulsant monotherapy in routine care of children and adolescents: levetiracetam fails more frequently than valproate and oxcarbazepine due to a lack of effectiveness. Eur J Pediatr 2014;173:87-92.
  • Bertsche A, Dahse AJ, Neininger MP, Bernhard MK, Syrbe S, Frontini R, Kiess W, Merkenschlager A, Bertsche T. Ambulatory care of children treated with anticonvulsants - pitfalls after discharge from hospital. Klin Padiatr 2013;225:277-82.
  • Bertsche T, Bertsche A, Krieg EM, Kunz N, Hanke G, Hoppe-Tichy T, Ebinger F, Haefeli WE. Prospective pilot intervention study to prevent medication errors in drugs administered to children by mouth or gastric tube: a programme for nurses, physicians und parents. Qual Saf Health Care 2010;19:e26.
  • Bertsche A, Bruehl C, Pietz J, Draguhn A. Region and pattern- specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices. Epilepsy Res 2010;88:118-26. 33. Bertsche A, Wagner MH, Bollmann R, Obladen M, Felderhoff-Müser U. An unusual manifestation of a neonatal Chlamydia infection. J Child Neurol 2008;23:948-9.
  • Jochum F, Loui A, Weber A, Felderhoff-Müser U, Bührer C, Dudenhausen JW, Obladen M. Low soluble Fas (sFas) and sFas ligand (sFasL) content in breast milk after preterm as opposed to term delivery. Acta Paediatr 2005;94:143-6.
  • Weber A, Dzietko M, Berns M, Felderhoff-Müser U, Heinemann U, Maier RF, Obladen M, Ikonomidou C, Bührer C. Neuronal damage after moderate hypoxia and high-dose erythropoietin. Neurobiol Dis 2005;20:594-600.
  • Hennermann JB, Weber A, Loui A, Mönch, E. Hyperphenylalaninemia in a premature infant being heterozygous for phenylketonuria. J Perinat Med 2004; 32:383-5.
  • Weber A, Maier RF, Hoffmann U, Grips M, Hoppenz M, Aktas AG, Heinemann U, Obladen M, Schuchmann S. Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures. Brain Res 2002;958:305-11.
  • Weber A, Loui A, Jochum F, Bührer C, Obladen, M. Breast milk from mothers of very low birthweight infants: variability in fat and protein content. Acta Paediatr 2001;90:772-5. 
  • Weber A, Maier RF, Felderhoff-Müser U, Lehmann R, Stöver B, Obladen M. Neonate with spinal hypoplasia on T12 and a localized vertebral malformation on L4. J Child Neurol 2001;16:619-21.
  • Morlion B, Ebner E, Weber A, Finke W, Puchstein C. Influence of bolus size on efficacy of postoperative patient-controlled analgesia with piritramide. Br J Anaesth 1999;82:52-5.

Publications – Other Articles (last update: March 16th, 2018)

  • Bertsche T, Pauschek J, Bernhard MK, Syrbe S, Nickel P, Merkenschlager A, Kiess W, Neininger MP, Bertsche A. Wie schätzen Kinder selbst ihre Epilepsie ein? Pädiatrie 2018, in press.
  • Bertsche T, Neininger MP, Kaune A, Schumacher MP, Dumeier HK, Bernhard MK, Syrbe S, Kiess W, Merkenschlager A, Bertsche A. Interdisziplinäre Konzepte von Pädiatrie und Klinischer Pharmazie zur Optimierung der Antikonvulsivatherapie. [Interdisciplinary concepts of paediatrics and clinical pharmacy to optimise anticonvulsant treatment]. Review. Klin Padiatr 2018;230:5-12.
  • Nickel P, Wolfram C, Pfeifer-Wiegleb D, Hornemann F, Kiess W, Merkenschlager A, Andreas A, Bertsche A. Herausforderungen in der psychologischen Diagnostik, Beratung und Therapie bei Kindern und Jugendlichen mit geistiger Behinderung und ihren Familien als interdisziplinärer Bestandteil innerhalb eines Sozialpädiatrischen Zentrums. Kinder- und Jugendmedizin 2017;17:293-300.
  • Bertsche A. Editorial Entwicklungsneurologie und Sozialpädiatrie. Kinder- und Jugendmedizin 2017;17:287.
  • Bertsche T, Pauschek J, Bernhard MK, Syrbe S, Nickel P, Merkenschlager A, Kiess W, Neininger MP, Bertsche A. Wie schätzen Kinder selbst ihre Epilepsie ein? Kinderärztliche Praxis 2017;88:368-372.
  • Pauschek J, Bernhard MK, Syrbe S, Nickel P, Neininger MP, Merkenschlager A, Kiess W, Bertsche T, Bertsche A. Response to the Response to Black R and Chin R’s letter on our article “Epilepsy in children and adolescents: Disease concepts, practical knowledge and coping”. Epilepsy Behav 2016; 62:77-312.
  • Neininger MP, Bertsche A, Frontini R, Prenzel F, Kiess W, Bertsche T. Salbutamol in acute bronchial obstruction - Prescribing practice in routine care. Kinder- und Jugendmedizin, 2015;15:433-438.
  • Schubert S, Neininger MP, Smers S, Winter A, Frontini R, Bertsche A, Bertsche T. Elektronische Arzneimittelverordnung - Autopilot in der Arzneimitteltherapie? Med Monatsschr Pharm 2015;38:224-30.
  • Bertsche A, Bernhard MK, Syrbe S, Merkenschlager A. Diagnostik und Therapie bei neonatalen Krampfanfällen. Kinder- und Jugendmedizin 2012;12:356-9.
  • Bernhard MK, Wolters B, Syrbe S, Landgraf M, Herbertz S, Bertsche A, Merkenschlager A. Antikonvulsive Therapie beginnen: ja! - aber wann wieder beeenden? Kinder- und Jugendmedizin 2012;12:362-7.
  • Wegmann F, Merkenschlager A, Sorge I, Bertsche A, Bernhard MK. Therapieschwierige Epilepsien am Beispiel der Rasmussen-Enzephalitis. Kinder- und Jugendmedizin 2012;12:368-70.
  • Syrbe S, Bernhard MK, Bertsche A, Hirsch W, Merkenschlager A. Die klassischen Phakomatosen. Eine kurze Übersicht und aktuelle Aspekte. Kinder- und Jugendmedizin 2012;12:376-81. 
  • Schober C, Syrbe S, Bernhard MK, Bertsche A, Hirsch W, Sorge I, Preuss M, Christiansen H, Merkenschlager A. Atypischer maligner Hirntumor mit multifokalem Befallsmuster. Kinder- und Jugendmedizin 2012;12:382-5.
  • Himpel M, Merkenschlager A, Syrbe S, Landgraf M, Bertsche A, Bernhard MK. Transkutane Elektrische Nervenstimulation (TENS) als Therapieoption der Spannungskopfschmerzen im Kindes- und Jugendalter. Kinder- und Jugendmedizin 2012;12:386-9.

Publications - Book chapters (last update: March 16th, 2018)

  • Baum P, Bertsche A, Matzen P: Grundzüge der Diagnostik. In Neuroorthopädie [Eds. P. Matzen, M. Deschauer, M. Kornhuber, U. Nestler]; De Gruyter, Berlin, Boston, 2017, pp. 71-101. ISBN 978-3-11-035242-9
  • Bertsche A, Neininger MP: Epilepsie. In Angewandte Phamakotherapie [Eds. O. Rose and K. Friedland]; Deutscher Apotheker Verlag, Stuttgart, 2015, pp. 187-200. ISBN 978-3-8047-3171-
  • Nieber K, Bertsche A: Management of attention-deficit/hyperactivity disorders: The role of psychosocial treatment and medication. In Beiträge zur Pädagogischen und Rehabilitationspsychologie Bd. 4: Historical and Cross-Cultural Aspects of Psychology [Eds. E. Witruk and A. Wilcke]; Peter Lang, Frankfurt a. Main, 2013, pp. 435-450. ISBN 978-3-631-63623-7  

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